RNase A Domain-Swapped Dimers Produced Through Different Methods: Structure–Catalytic Properties and Antitumor Activity
نویسندگان
چکیده
منابع مشابه
Linking in domain-swapped protein dimers
The presence of knots has been observed in a small fraction of single-domain proteins and related to their thermodynamic and kinetic properties. The exchanging of identical structural elements, typical of domain-swapped proteins, makes such dimers suitable candidates to validate the possibility that mutual entanglement between chains may play a similar role for protein complexes. We suggest tha...
متن کاملStructures of the two 3D domain-swapped RNase A trimers.
When concentrated in mildly acidic solutions, bovine pancreatic ribonuclease (RNase A) forms long-lived oligomers including two types of dimer, two types of trimer, and higher oligomers. In previous crystallographic work, we found that the major dimeric component forms by a swapping of the C-terminal beta-strands between the monomers, and that the minor dimeric component forms by swapping the N...
متن کاملDesign of three-dimensional domain-swapped dimers and fibrous oligomers.
Three-dimensional (3D) domain-swapped proteins are intermolecularly folded analogs of monomeric proteins; both are stabilized by the identical interactions, but the individual domains interact intramolecularly in monomeric proteins, whereas they form intermolecular interactions in 3D domain-swapped structures. The structures and conditions of formation of several domain-swapped dimers and trime...
متن کاملThe crystal structure of a 3D domain-swapped dimer of RNase A at a 2.1-A resolution.
The dimer of bovine pancreatic ribonuclease A (RNase A) discovered by Crestfield, Stein, and Moore in 1962 has been crystallized and its structure determined and refined to a 2.1-A resolution. The dimer is 3D domain-swapped. The N-terminal helix (residues 1-15) of each subunit is swapped into the major domain (residues 23-124) of the other subunit. The dimer of bull seminal ribonuclease (BS-RNa...
متن کاملcomparative dna interaction studies of antiviral drug, zidovudine and its complex using different instrumental methods
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ژورنال
عنوان ژورنال: Life
سال: 2021
ISSN: 2075-1729
DOI: 10.3390/life11020168